| Date | Opponent | Time/TV | Tickets | |
| Saturday Sep 3, 2022 |  | at San Diego State Aztecs Aztec Stadium, San Diego, CA | 3:30 PM ET CBS | Won 38-20 |
| Saturday Sep 10, 2022 |  | Mississippi State Bulldogs Arizona Stadium, Tucson, AZ | 11:00 PM ET FS1 | Lost 39-17 |
| Saturday Sep 17, 2022 |  | North Dakota State Bison Arizona Stadium, Tucson, AZ | 11:00 PM ET FS1 | Won 31-28 |
| Saturday Sep 24, 2022 |  | at California Golden Bears California Memorial Stadium, Berkeley, CA | 5:30 PM ET Pac-12 Network | Lost 49-31 |
| Saturday Oct 1, 2022 |  | Colorado Buffaloes Arizona Stadium, Tucson, AZ | 9:30 PM ET Pac-12 Network | Won 43-20 |
| Saturday Oct 8, 2022 |  | Oregon Ducks Arizona Stadium, Tucson, AZ | 9:00 PM ET Pac-12 Network | Lost 49-22 |
| Saturday Oct 15, 2022 |  | at Washington Huskies Husky Stadium, Seattle, WA | 5:30 PM ET Pac-12 Network | Lost 49-39 |
| Saturday Oct 22, 2022 | Bye Week | |||
| Saturday Oct 29, 2022 |  | USC Trojans Arizona Stadium, Tucson, AZ | 7:00 PM ET P12N | Lost 45-37 |
| Saturday Nov 5, 2022 |  | at Utah Utes Rice-Eccles Stadium, Salt Lake City, UT | 7:30 PM ET P12N | Lost 45-20 |
| Saturday Nov 12, 2022 |  | at UCLA Bruins Rose Bowl Stadium, Pasadena, CA | 10:30 PM ET FOX | Won 34-28 |
| Saturday Nov 19, 2022 |  | Washington State Cougars Arizona Stadium, Tucson, AZ | 2:00 PM ET Pac-12 Network | Lost 31-20 |
| Friday Nov 25, 2022 |  | Arizona State Sun Devils Arizona Stadium, Tucson, AZ | 3:00 PM ET FS1 | Won 38-35 |
