| Date | Opponent | Time/TV | Tickets | |
| Monday November 1, 2021 |  | Eastern New Mexico Greyhounds Exhibition McKale Center, Tucson, AZ | 7:00 PM MST PAC-12 Network | Won 96-50 |
| Tuesday November 9, 2021 |  | Northern Arizona Lumberjacks McKale Center, Tucson, AZ | 8:30 PM MST PAC-12 Network Arizona | Won 81-52 |
| Friday November 12, 2021 |  | University of Texas-Rio Grande Valley McKale Center, Tucson, AZ | 7:00 PM MST PAC-12 Network | Won 104-50 |
| Tuesday November 16, 2021 |  | North Dakota State Bison McKale Center, Tucson, AZ | 7:00 PM MST PAC-12 Network | Won 97-45 |
| Friday November 19, 2021 |  | Wichita State Shockers Roman Main Event T-Mobile Arena, Las Vegas, NV | 8:00 PM MST ESPNU | Won 82-78 (OT) |
| Sunday November 21, 2021 |  | Michigan Wolverines Roman Main Event T-Mobile Arena, Las Vegas, NV | 7:30 PM MST ESPN | Won 80-62 |
| Saturday November 27, 2021 |  | Sacramento State Hornets McKale Center, Tucson, AZ | 5:30 PM MST PAC-12 Network Arizona | Won 105-59 |
| Sunday December 5, 2021 |  | at Oregon State Beavers Gill Coliseum, Corvallis, OR | 2:00 PM MST ESPNU | Won 90-65 |
| Wednesday December 8, 2021 |  | Wyoming Cowboys McKale Center, Tucson, AZ | 8:00 PM MST PAC-12 Network | Won 94-65 |
| Saturday December 11, 2021 |  | at Illinois Fighting Illini State Farm Center, Champaign, IL | 3:00 PM MST FOX | Won 83-79 |
| Wednesday December 15, 2021 |  | Northern Colorado Bears McKale Center, Tucson, AZ | 7:00 PM MST PAC-12 Network | Won 101-76 |
| Saturday December 18, 2021 |  | Cal Baptist Lancers McKale Center, Tucson, AZ | 4:00 PM MST PAC-12 Network | Won 84-60 |
| Wednesday December 22, 2021 |  | at Tennessee Volunteers Thompson Boling Arena, Knoxville, TN | 5:00 PM MST ESPN2 | Lost 77-73 |
| Monday Jan 3, 2022 |  | Washington Huskies McKale Center, Tucson, AZ | 6:00 PM MST PAC-12 Network | Won 95-79 |
| Thursday January 13, 2022 |  | Colorado Buffaloes McKale Center, Tucson, AZ | 9:00 PM MST FS1 | Won 76-55 |
| Saturday January 15, 2022 |  | Utah Utes McKale Center, Tucson, AZ | 6:00 PM MST PAC-12 Network | Won 82-64 |
| Thursday January 20, 2022 |  | at Stanford Cardinal Maples Pavilion, Stanford, CA | 9:00 PM MST ESPNU | Won 85-57 |
| Sunday January 23, 2022 |  | at California Golden Bears Haas Pavilion, Berkeley, CA | 1:00 PM MST PAC-12 Network | Won 96-71 |
| Tuesday January 25, 2022 |  | at UCLA Bruins Pauley Pavilion, Los Angeles, CA | 9:00 PM MST ESPN | Lost 75-59 |
| Saturday January 29, 2022 |  | Arizona State Sun Devils McKale Center, Tucson, AZ | 12:30 PM MST CBS | Won 67-56 |
| Thursday February 3, 2022 | | UCLA Bruins McKale Center, Tucson, AZ | 6:00 PM MST ESPN | Won 76-66 |
| Saturday February 5, 2022 |  | USC Trojans McKale Center, Tucson, AZ | 3:00 PM MST FOX | Won 72-63 |
| Monday February 7, 2022 | | at Arizona State Sun Devils Desert Financial Arena, Tempe, AZ | 7:00 PM MST FS1 | Won 91-79 |
| Thursday February 10, 2022 |  | at Washington State Cougars Beasley Coliseum, Pullman, WA | 7:00 PM MST FS1 | Won 72-60 |
| Saturday February 12, 2022 | | at Washington Huskies Alaska Airlines Arena at Hec Edmundson Pavilion, Seattle, WA | 4:00 PM MST PAC-12 Network | Won 92-68 |
| Thursday February 17, 2022 | | Oregon State Beavers McKale Center, Tucson, AZ | 5:30 PM MST PAC-12 Network | Won 83-63 |
| Saturday February 19, 2022 |  | Oregon Ducks McKale Center, Tucson, AZ | 8:00 PM MST ESPN or ESPN2 | Won 84-81 |
| Thursday February 24, 2022 | | at Utah Utes Jon M. Huntsman Center, Salt Lake City, UT | 9:00 PM MST FS1 | Won 97-77 |
| Saturday February 26, 2022 | | at Colorado Buffaloes CU Events Center, Boulder, CO | 6:00 PM MST ESPN2 or ESPNU | Lost 79-63 |
| Tuesday March 1, 2022 | | at USC Trojans Galen Center, Los Angeles, CA | 9:00 PM MST ESPN | Won 91-71 |
| Thursday March 3, 2022 | | Stanford Cardinal McKale Center, Tucson, AZ | 7:00 PM MST ESPN2 or ESPNU | Won 81-69 |
| Saturday March 5, 2022 | | California Golden Bears McKale Center, Tucson, AZ | 3:00 PM MST PAC-12 Network | Won 89-61 |
| Thursday March 10, 2022 | | Stanford Cardinal Pac 12 Tournament T-Mobile Arena in Las Vegas, NV | 1:00 PM MST PAC-12 Network | Won 84-80 |
| Friday March 11, 2022 | | Colorado Buffaloes Pac 12 Tournament T-Mobile Arena in Las Vegas, NV | 7:00 PM MST PAC-12 Network | Won 82-72 |
| Saturday March 12, 2022 | | UCLA Bruins Pac 12 Tournament T-Mobile Arena in Las Vegas, NV | 7:00 PM MST Fox | Won 84-76 |
| Friday March 18, 2022 |  | Wright State Raiders NCAA Tournament Viejas Arena, San Diego, CA | 4:27 PM MST TRUTV | Won 87-70 |
| Sunday March 20, 2022 |  | TCU Horned Frogs NCAA Tournament Viejas Arena, San Diego, CA | 6:40 PM MST TBS | Won 85-80 (OT) |
| Thursday March 24, 2022 |  | Houston Cougars NCAA Tournament AT&T Center, San Antonio, TX | 6:55 PM MST TBS | Lost 72-60 |
